Early Onset Werner Syndrome

Werner syndrome (WS) was a rare genetic disorder characterized by early onset of aging symptoms and metabolic disorders. This case study reported a 27-year-old female who exhibited symptoms such as global hair loss, bird-like facial features, and various metabolic and congenital issues, including diabetes, dyslipidemia, cataracts, and hearing loss, from a young age. Despite intensive treatment, she had severe insulin resistance and hypertriglyceridemia. The study highlighted the importance of considering WS in cases of early-onset type 2 diabetes and hyperlipidemia, especially when accompanied by other atypical symptoms.