The Dutasteride: Miraculous Drug in Alopecia Treatment - A Review

August 2023 in “ Zenodo (CERN European Organization for Nuclear Research) ”

Shaikh A Z, Vathsala Patil, Shivajirao R. Patil, Pawar S P

Dutasteride 5-alpha reductase inhibitor dihydrotestosterone DHT androgenetic alopecia AGA benign prostatic hyperplasia BPH Avodart

TLDR Dutasteride effectively treats hair loss and prostate issues.

This review paper provides an in-depth analysis of Dutasteride, a potent 5-alpha reductase inhibitor, focusing on its pharmacological properties and therapeutic applications. It highlights Dutasteride's mechanism of action in reducing dihydrotestosterone (DHT) levels by inhibiting both types I and II 5-alpha reductase enzymes. The paper examines its efficacy in treating androgenetic alopecia (AGA) and benign prostatic hyperplasia (BPH), noting improvements in symptom relief, urinary flow rates, and prostate size reduction. Additionally, the review discusses the potential benefits of combining Dutasteride with alpha-blockers and its investigational role in prostate cancer prevention and transgender medicine. The paper aims to inform healthcare professionals about the clinical applications of Dutasteride, particularly in promoting hair growth and managing conditions related to androgen excess.

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community The Real Cause Of Androgenetic Alopecia

in Research/Science 674 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community My good/bad experience with Creatine

in Treatment 23 upvotes 7 months ago

Creatine may cause increased hair shedding in some individuals, especially those with androgenetic alopecia (AGA), despite its physical performance benefits. Many users report stopping creatine to reduce hair loss, while others believe the effects are anecdotal or due to other factors like increased physical activity.

community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.

in Research/Science 104 upvotes 3 years ago

Most hair loss treatments are ineffective; only finasteride, dutasteride, and minoxidil show effectiveness.

community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

in Finasteride/Dutasteride 72 upvotes 2 years ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.

community Saying creatine causes loss on fin/dut makes no sense and this is why

in Finasteride/Dutasteride 42 upvotes 1 year ago

The conversation discusses whether creatine causes hair loss for those using finasteride or dutasteride, with some suggesting creatine might increase DHT or upregulate androgen receptors, potentially leading to hair loss. Others argue the evidence is not conclusive, citing limited studies and personal anecdotes, with some avoiding creatine as a precaution.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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