Dutasteride: A Review of Current Data on a Novel Dual Inhibitor of 5-Alpha Reductase

Dutasteride was used to treat benign prostatic hyperplasia by inhibiting both isoenzymes of 5alpha reductase, leading to a significant reduction in serum dihydrotestosterone. Clinical trials demonstrated its effectiveness in reducing prostate volume, improving urinary symptoms, and decreasing the need for surgery. Side effects included decreased libido, erectile dysfunction, and gynecomastia, but these were only slightly more common than with placebo. Long-term use did not increase side effects, and combining dutasteride with tamsulosin was effective for patients with large prostate volumes. Additionally, dutasteride's potential anticancer properties were under investigation in the REDUCE trial.