Evaluation of the Effects of Dorema Aucheri Hydroalcoholic Extract on Wound Healing of Streptozotocin-Induced Diabetic Rats: A Stereological Study

The study evaluated the effects of Dorema aucheri hydroalcoholic extract on wound healing in streptozotocin-induced diabetic rats. Conducted on 48 male rats divided into 6 groups, the research found that a 5% concentration of D. aucheri extract significantly improved wound healing, re-epithelialization, collagen deposition, and neovascularization compared to other groups (p ≤ 0.05). However, the 10% extract group showed lower fibroblast, collagen, and hair follicle densities (p ≤ 0.001). The findings suggest that a 5% concentration of D. aucheri extract is particularly effective in enhancing the healing of diabetic wounds.