Blood Donors on Teratogenic Drugs and Donor Deferral Periods in a Clinical Situation

December 2011 in “ Vox Sanguinis ”

Soo Youn Shin, Young Hack Shin, S. W. Lee, Jong-Il Shin, C. H. Kim

finasteride isotretinoin acitretin etretinate dutasteride high-performance liquid chromatography Propecia Accutane Claravis Soriatane Avodart HPLC

TLDR Some blood donors on teratogenic drugs may have unsafe drug levels, suggesting a need for better deferral policies.

The study analyzed 167 stored blood specimens from donors who had taken teratogenic drugs and whose blood was transfused to women of childbearing age. The aim was to determine the plasma concentration of these drugs at the time of donation using high-performance liquid chromatography. The results showed that the numbers of specimens exceeding the quantification limit were 7 for finasteride, 39 for isotretinoin, 4 for acitretin, 2 for etretinate, and 1 for dutasteride. Notably, one specimen of finasteride was beyond the recommended drug deferral period. These findings were intended to aid in the development of practical deferral policies for blood donors on teratogenic medications.

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