Cross-Species Sensitivity to a Novel Androgen Receptor Agonist of Potential Environmental Concern, Spironolactone

Men discussing the use of oral spironolactone for androgenetic alopecia, with some reporting no immediate changes in hair but noticing clearer skin and weight loss. Concerns about side effects like gynecomastia and erectile dysfunction are mentioned, with users planning to adjust doses over time.

Spironolactone and finasteride are not recommended for women planning pregnancy due to birth defect risks. Both need to be stopped months before conception, and finasteride is generally not advised for women.

The user was prescribed topical Spironolactone instead of Finasteride for hair loss, but is concerned about its effectiveness and potential side effects. Other users suggest that topical Spironolactone is safe for men, but Finasteride might be a more common and effective choice.

Spironolactone and estrogen may be more effective for hair regrowth in transgender women than finasteride alone. Estrogen and spironolactone suppress testosterone, potentially reducing DHT more effectively than finasteride.

Topical spironolactone is considered safe for males but is not very effective for hair loss. Some users suggest trying it since it's already purchased, while others recommend alternatives like clascoterone.

A 23-year-old has been using finasteride, dutasteride, and spironolactone to combat hair loss and hormonal acne, with mixed results and concerns about side effects. The user is experimenting with spironolactone despite its potential risks, hoping for skin and body hair improvements.