Cronkhite–Canada Syndrome With Multiple Mesenteric Lymphadenopathy: A Case Report
December 2025
in “
JGH Open
”
New to Prednisolone? There is a guide in the encyclopedia. Read the guide → Studysummary In this case study, a 78-year-old Japanese woman with Cronkhite-Canada syndrome experienced mesenteric lymphadenopathy, which reduced in size after treatment with the corticosteroid prednisolone. This suggests that mesenteric lymphadenopathy, though uncommon in CCS, may respond to steroid therapy.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
This case report discusses a rare instance of Cronkhite–Canada syndrome (CCS) in a 78-year-old Japanese woman, highlighting the unusual presence of multiple mesenteric lymphadenopathies observed via CT imaging. CCS is characterized by symptoms such as chronic diarrhea, alopecia, and nail atrophy, and is associated with a high risk of gastrointestinal malignancies. The patient's lymphadenopathy resolved following treatment with oral prednisolone, suggesting an association with CCS rather than malignancy. The report emphasizes the importance of early diagnosis and treatment to improve outcomes in CCS, noting that mesenteric lymphadenopathy, although uncommon, can occur and may regress with corticosteroid therapy. The study also underscores the need for further research to understand the underlying mechanisms of lymphadenopathy in CCS.
