CRISPR/Cas9-Mediated Generation of <i>COL7A1</i>-Deficient Keratinocyte Model of Recessive Dystrophic Epidermolysis Bullosa.

October 2023 in “ PubMed ”

Farzad Alipour, Mana Ahmadraji, Elham Yektadoost, Parvaneh Mohammadi, Hossein Baharvand, Mohsen Basiri

CRISPR/Cas9 COL7A1 keratinocyte Recessive Dystrophic Epidermolysis Bullosa RDEB

TLDR Scientists created a cell model to study and find treatments for a skin disease called RDEB.

The study successfully developed the first isogenic immortalized keratinocyte lines deficient in the <i>COL7A1</i> gene, creating a valuable cell culture model for researching Recessive Dystrophic Epidermolysis Bullosa (RDEB). This model facilitates the exploration of RDEB biology and the evaluation of potential therapeutic strategies.

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Research cited in this study

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research Defining MicroRNA Signatures of Hair Follicular Stem and Progenitor Cells in Healthy and Androgenic Alopecia Patients

12 citations , November 2020 in “Journal of Dermatological Science”

Found microRNA differences in hair cells, suggesting potential treatment targets for hair loss.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

MagicBold in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Why is nobody studying the difference between donor and balding hair?

in Chat 89 upvotes 1 year ago

The conversation discusses why the difference between donor and balding hair isn't studied more to find a cure for hair loss. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community I believe CRISPR-on & CRISPR-off is an ultimate CURE for baldness, unlike Hair Cloning or hair loss treatments.

in Research/Science 23 upvotes 4 years ago

The conversation discusses CRISPR-on & CRISPR-off as a potential cure for baldness, contrasting it with hair cloning and other treatments like Minoxidil, finasteride, and RU58841. It also mentions the potential of mRNA for gene expression control and the prioritization of gene editing for severe genetic conditions.

community Target Area Hair Count (TAHC) increase comparasion of all future treatments in clinical trial phases

in Research/Science 35 upvotes 1 year ago

Finasteride, Minoxidil, Bioneer CosmeRNA, Technoderma, Kintor, Hope, Breezula, and Follicum treatments showed increases in hair count, with Technoderma showing the highest increase at 24.3 hairs/cm². Amplifica has not yet published results.

community The pessimism about the Crisp Cas 9 is excessive

in Chat 12 upvotes 5 months ago

CRISPR Cas9 could potentially treat baldness by targeting specific genes in hair follicles without affecting other body functions. There is optimism about its future use, despite ethical concerns and the current reliance on treatments like minoxidil and finasteride.

community CRISPR Is Curing People Right Now. Genetic Hair Loss is Next?

in Technology 110 upvotes 1 year ago

CRISPR shows promise for treating hair loss by targeting specific genes. Current treatments include Minoxidil and finasteride, but CRISPR could offer a more precise solution, though it is still expensive and in early stages.

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research CRISPR/Cas9-Mediated Generation of COL7A1-Deficient Keratinocyte Model of Recessive Dystrophic Epidermolysis Bullosa

June 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Scientists created cell lines to study a genetic skin disorder using CRISPR technology.

ESGCT and FSGT Collaborative Congress Helsinki, Finland September 17–20, 2015 Abstracts