Creatine Phosphokinase Levels and Isotretinoin Therapy

    November 1987 in “ Journal of The American Academy of Dermatology ”
    Joel S. Koransky
    Image of study
    TLDR Isotretinoin can raise CPK levels, so patients need monitoring, especially before surgery.
    The document discussed the occurrence of elevated creatine phosphokinase (CPK) levels during isotretinoin therapy, illustrated by a case report of a 17-year-old male with nodulocystic acne. After 4 weeks of isotretinoin treatment, his CPK level was 374 IU/liter (normal: 0-200 IU/liter). The elevated CPK level led to the postponement of a scheduled surgery. Upon discontinuation of isotretinoin, his CPK levels normalized, and he successfully underwent surgery. Elevated CPK levels are generally associated with a risk of malignant hyperthermia during anesthesia, but the exact relationship between isotretinoin and this risk remains unclear. The document emphasized the importance of monitoring CPK levels in patients on isotretinoin, especially if surgery is planned.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 594 results

      community Creatine is the opposite of minoxidil !

      in Research/Science  322 upvotes 2 weeks ago
      Creatine may counteract minoxidil's hair growth effects by closing potassium ATP channels, potentially leading to hair loss in predisposed individuals. Despite anecdotal reports, there is no conclusive evidence linking creatine to hair loss.

      community Creatine and ru-58841 experiences?

      in Chat  1 upvotes 1 month ago
      RU58841 is preferred over finasteride for blocking DHT on the scalp, especially for those with aggressive MPB. Creatine is associated with increased hair shedding, even when using RU58841.

    Similar Research

    5 / 1000+ results