Cutaneous Overexpression of Cyclooxygenase-2 Models Androgenetic Alopecia in Adult Mice

April 2021 in “ Journal of Investigative Dermatology ”

Claire Hopkins, Y. H. Zheng, R. Yang, Arben Nace, Elena Bernardis, Jang-Hsing Hsieh, George Cotsarelis

cyclooxygenase-2 androgenetic alopecia prostaglandin signaling hair loss cellular mechanisms AGA COX-2

TLDR Cyclooxygenase-2 overexpression in mice skin causes hair loss like human androgenetic alopecia.

The document titled "607 Cutaneous overexpression of cyclooxygenase-2 models androgenetic alopecia in adult mice" discusses a study where researchers overexpressed cyclooxygenase-2 in the skin of adult mice, which resulted in hair loss similar to androgenetic alopecia in humans. The study suggests that cyclooxygenase-2 and prostaglandin signaling may play a role in the development of androgenetic alopecia and could be potential targets for treatment. The study provides a new tool for studying the cellular mechanisms of AGA.

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