Telescope Model for Coordinated Organ Morphogenesis and Stem Cell Formation

    April 2023 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    R. Morita
    Image of study
    TLDR Developing hair follicles form from ring-shaped patterns, with future stem cells originating from the outer ring, not the upper layers, as previously thought.
    The study elucidates the developmental process of hair follicle stem cells using a combination of long-term 3D live imaging and single-cell transcriptomics, resulting in a dynamic 4D atlas of cellular dynamics, cell lineages, and transcriptome changes in developing mouse hair follicles. The findings reveal that hair follicles develop through cylindrical compartments formed from concentric ring-shaped cell pre-patterns in the hair follicle placode. Future hair follicle stem cells originate from the peripheral ring compartment of the placode, not from previously suggested suprabasal cells. This developmental process, termed the "telescope model," explains the spatiotemporal coordination of tissue morphogenesis and cell fate specification during the formation of 3D cylindrical compartments consisting of various epithelial cell lineages, including stem cell lineages.
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