Faculty Opinions Recommendation of Conditional Telomerase Induction Causes Proliferation of Hair Follicle Stem Cells

    October 2005 in “ Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ”
    Michael R. Gold
    Studysummary This study found that induced TERT expression in mouse skin epithelium rapidly transitions hair growth from the resting to active phase by promoting stem cell proliferation through a non-telomere related mechanism.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 4

    1. Manipulation of Stem Cell Proliferation and Lineage Commitment: Visualization of Label-Retaining Cells in Wholemounts of Mouse Epidermis Development · 2003
    2. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003
    3. Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis Cell · 2000
    4. Induction of the Hair Growth Phase in Postnatal Mice by Localized Transient Expression of Sonic Hedgehog Journal of Clinical Investigation · 1999