Commentary: Darier-White Disease

    January 1983 in “ Archives of dermatology ”
    Rhonda Rand
    TLDR The conclusion is that Darier-White disease was accurately described by White but he missed the key feature of dyskeratotic cells which Darier identified.
    In 1889, James C. White and Ferdinand Jean Darier independently described a skin condition now known as Darier-White disease. White's clinical description was detailed but missed identifying dyskeratotic cells, the key histopathologic feature of the disorder, and incorrectly suggested that hair follicles were primarily affected. Darier correctly identified the dyskeratotic regions in the epidermis. This condition, also referred to as keratosis follicularis or psorospermose folliculaire végétante, became recognized as a distinct dermatological entity.
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