TLDR Nanotechnology improves Clomiphene citrate's effectiveness and reduces side effects for treating ovulatory disorders.
The document discusses the application of nanotechnology to improve the effectiveness and reduce the side effects of Clomiphene citrate, a drug used to treat ovulatory disorders. Clomiphene citrate stimulates ovulation by increasing the amount of follicle-stimulating hormone (FSH) exposed to the ovary, and has been found to restore ovulation in about 80% of treated individuals. Nanotechnology can enhance the solubility of Clomiphene citrate and limit its side effects. For example, a nanosized Clomiphene citrate-encapsulating Phosal-based formulation (PBF) has been developed to reduce the drug's negative effects on the endometrium. Additionally, nanosuspensions using PVP K-30 and Tween-80 have been created to enhance the drug's solubility. The document also discusses hyphenated techniques for analyzing and quantifying Clomiphene citrate in solvents and biological samples.
257 citations,
July 2018 in “Obstetrics & Gynecology” PCOS is a complex disorder in women that can lead to various health risks and requires personalized treatment.
22 citations,
June 2017 in “Advances in Clinical and Experimental Medicine” Polycystic ovary syndrome (PCOS) was first described in 1721, officially diagnosed in the 1990s, and is now known to be partly genetic and linked to insulin resistance, with increased risk of cardiovascular disease and carbohydrate metabolism issues.
41 citations,
April 1997 in “Fertility and sterility” Clomiphene citrate can reverse low hormone levels and symptoms in male runners with hypogonadotropic hypogonadism.
2 citations,
March 2017 in “Canadian Urological Association journal” Clomiphene citrate improves fertility in men taking finasteride for hair loss.
July 2023 in “Journal of Clinical Medicine” Choosing the right starting dose of Clomiphene Citrate for ovulation induction in PCOS women is challenging; higher BMI and hormone levels may indicate resistance to the standard dose.
September 2018 in “The Journal of Urology” Clomiphene citrate is a cheap and simple treatment for low testosterone that works as well as human chorionic gonadotropin, alone or combined, especially for men who want to keep their fertility.
9 citations,
May 2017 in “Gynecological Endocrinology” Transvaginal hydrolaparoscopy is effective for increasing ovulation and pregnancy rates in women with PCOS who didn't respond to clomiphene.
