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Glossary Endometrium

inner lining of uterus that thickens and sheds monthly

The endometrium is the inner lining of the uterus, which thickens during the menstrual cycle in preparation for a potential pregnancy. If fertilization does not occur, this lining is shed during menstruation. This tissue is crucial for reproductive health and is involved in conditions such as endometriosis and endometrial cancer.

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Research

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Overactivated Sonic Hedgehog Signaling Aggravates Intrauterine Adhesion by Inhibiting Autophagy in Endometrial Stromal Cells

research Overactivated sonic hedgehog signaling aggravates intrauterine adhesion via inhibiting autophagy in endometrial stromal cells

52 citations , September 2020 in “Cell Death and Disease”

This study found that impaired autophagy plays a role in sonic hedgehog pathway-induced endometrial fibrosis, suggesting it as a potential target for treating intrauterine adhesion.

research Overexpression of IL-18 in the Proliferative Phase Endometrium of Patients With Polycystic Ovary Syndrome

21 citations , June 2016 in “Reproductive Sciences”

This study found increased IL-18 levels in the endometrium of women with polycystic ovary syndrome, especially in those who are overweight, suggesting a link with body mass index.

Testosterone Reduces Tight Junction Complexity and Down-Regulates Expression of Claudin-4 and Occludin in the Endometrium in Ovariectomized, Sex-Steroid Replacement Rats

research Testosterone Reduces Tight Junction Complexity and Down-regulates Expression of Claudin-4 and Occludin in the Endometrium in Ovariectomized, Sex-steroid Replacement Rats

10 citations , December 2019 in “in Vivo”

This study found that administering testosterone to ovariectomized female rats decreased endometrial tight junction complexity and expression of specific proteins, potentially affecting embryo implantation.

research Angiogenic factor-driven improvement of refractory thin endometrium with autologous platelet-rich plasma intrauterine infusion in frozen embryo transfer cycles

9 citations , September 2024 in “Frontiers in Endocrinology”

This study found that intrauterine PRP infusion is a safe and effective treatment for patients with refractory thin endometrium and implantation failures, with the improvement primarily driven by the angiogenic cytokines in PRP.

Intrauterine Botulinum Toxin A Administration Promotes Endometrial Regeneration Mediated by IGFBP3-Dependent OPN Proteolytic Cleavage in Thin Endometrium

research Intrauterine botulinum toxin A administration promotes endometrial regeneration mediated by IGFBP3-dependent OPN proteolytic cleavage in thin endometrium

9 citations , January 2023 in “Cellular and Molecular Life Sciences”

This study found that intrauterine administration of botulinum toxin A improved endometrial environment and receptivity in a murine model of thin endometrium through mechanisms involving IGFBP3 and osteopontin.

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community HMI-115 update: Chime Biologics and Hope Medicine Enter Manufacturing Agreement to Speed up the Launch of First-in-class Antibody Drug HMI-115 Targeting Endometriosis and Androgenic Alopecia

110 upvotes 2 years ago

Chime Biologics and Hope Medicine are speeding up the launch of a first-in-class antibody drug, HMI-115, for endometriosis and androgenic alopecia. The treatment involves a series of subcutaneous injections, has shown promising results in phase 1, and continues to promote hair regrowth even after the treatment is stopped.

community Average r/bald user complaining

401 upvotes 9 months ago

Hair loss treatments like Minoxidil, finasteride, and RU58841, focusing on their effectiveness and side effects. It also highlights the disparity in medical research funding between hair loss and conditions like endometriosis.

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