Clinicopathological characteristics of fibrosing alopecia in a pattern distribution: a single‐center, retrospective study

    September 2023 in “International Journal of Dermatology
    Kelu Wei, Chunya Ni, Qiong Huang, Kai Yang, Yue Zhang, Qingmei Liu, Yu'ou Sha, Qiaoan Zhang, Jinran Lin, Wenyu Wu
    TLDR Younger people are at a higher risk for Fibrosing Alopecia in a Pattern Distribution than previously thought, with common symptoms and possible involvement of mast cells in its development.
    This retrospective study analyzed 20 Chinese patients with Fibrosing Alopecia in a Pattern Distribution (FAPD), a subtype of primary lymphocytic cicatricial alopecia. The mean age at diagnosis was 33.45 years, and the disease duration was 7.43 years on average. 65% of the patients had a family history of hair loss. The study found that the younger population is at a higher risk than previously thought. Trichoscopic findings showed hair diameter variability, perifollicular erythema, loss of follicular ostia, and peripilar casts in all patients. Histopathological findings revealed a decrease in total hair and terminal hair, with an increase in vellus-like hair. The histopathology of FAPD typically shows features of both lichen planopilaris (LPP) and androgenetic alopecia (AGA). The study suggests that mast cells might play a role in the pathogenesis of FAPD.
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