TLDR Younger people are at a higher risk for Fibrosing Alopecia in a Pattern Distribution than previously thought, with common symptoms and possible involvement of mast cells in its development.
This retrospective study analyzed 20 Chinese patients with Fibrosing Alopecia in a Pattern Distribution (FAPD), a subtype of primary lymphocytic cicatricial alopecia. The mean age at diagnosis was 33.45 years, and the disease duration was 7.43 years on average. 65% of the patients had a family history of hair loss. The study found that the younger population is at a higher risk than previously thought. Trichoscopic findings showed hair diameter variability, perifollicular erythema, loss of follicular ostia, and peripilar casts in all patients. Histopathological findings revealed a decrease in total hair and terminal hair, with an increase in vellus-like hair. The histopathology of FAPD typically shows features of both lichen planopilaris (LPP) and androgenetic alopecia (AGA). The study suggests that mast cells might play a role in the pathogenesis of FAPD.View this study on onlinelibrary.wiley.com →
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Fibrosing alopecia in a pattern distribution is a hair loss condition often confused with other types, requiring early treatment but usually not resulting in significant hair regrowth.
Asian hair is generally straight and thick, with unique disorders and properties, and more research is needed to understand it fully.
FAPD is a possible diagnosis for hair loss in patients of color and requires multiple evaluations for accurate diagnosis.
Androgenetic alopecia, a common hair loss condition, can be treated with topical minoxidil, oral finasteride, or oral spironolactone, and new treatments like platelet-rich plasma, low-level laser therapy, and janus-kinase inhibitors are being explored.
Androgenetic alopecia (AGA) is a common, hereditary hair loss condition that can be slowed but not permanently reversed with available therapies.
Male pattern hair loss caused by follicular miniaturization; early diagnosis and treatment can reduce psychological burden.
Two teenage brothers had a rare, treatment-resistant form of female-pattern hair loss with unusual scalp changes.
Minoxidil promotes hair growth but exact mechanism is unknown.