Clinical Snippets: Dermatological Studies and Findings
June 2004
in “
Journal of Investigative Dermatology
”
TLDR Apoptosis may play a role in feather and hair development, SF-36 is better for mental health in skin patients, a psoriasis gene is found in Caucasians, eosinophils might not be crucial for some skin allergies, and changes in atopic dermatitis could increase skin sensitivity.
The document discussed various dermatological studies and findings. It highlighted the role of apoptosis in feather morphogenesis and its potential similarities to hair development. Wallenhammer et al. found that the SF-36 quality-of-life assessment tool was more effective for mental health evaluation than the DLQI in skin disease patients. Sagoo and coworkers identified a psoriasis susceptibility gene at 4q28–31 in Caucasians, previously linked to the Chinese Han population. Jensen and colleagues discovered that eosinophils might not be essential for certain phases of skin allergic reactions, as anti-IL-5 treatment reduced eosinophils without altering allergic response phases. Additionally, they noted biochemical alterations in atopic dermatitis, such as reduced sphingomyelinases and ceramides, which could increase skin sensitivity and disease susceptibility.
