A Clinical Review of Trichorrhexis Nodosa

March 2025 in “ The Open Dermatology Journal ”

Craig G. Burkhart

trichorrhexis nodosa hair breakage nodular swellings chemical treatments heat treatments formaldehyde glyoxylic acid cysteine treatments post-translational modifications RNA interference hair shaft gentle hair care products

TLDR Trichorrhexis nodosa is common hair breakage, often due to styling, and new treatments are being explored.

Trichorrhexis nodosa (TN) is the most common form of hair breakage, characterized by nodular swellings along the hair shaft. It can be congenital or acquired, with the proximal form being prevalent among African Americans due to chemical and heat treatments. Treatment involves minimizing heat styling and using gentle hair care products. The FDA's potential restriction on formaldehyde in hair treatments could impact current practices, prompting the use of alternatives like glyoxylic acid and cysteine treatments. Recent genetic research has identified new therapeutic targets, such as post-translational modifications and RNA interference, offering promising new treatment avenues for TN.

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research The Structure of People's Hair

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research Formaldehyde Replacement with Glyoxylic Acid in Semipermanent Hair Straightening: A New and Multidisciplinary Investigation

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Chemical hair straightening can damage hair and health, needing safer alternatives and stricter regulations.

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Localized trichorrhexis nodosa is a hair condition where hair becomes fragile and breaks easily due to damage.

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The hair disorder was caused by abnormal protein formation, making hair easily damaged.

Semantic ratio: 80%