Clinical Profile and Outcomes of Patients with Polycystic Ovarian Syndrome
August 2025
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Studysummary In this prospective observational study at a tertiary care center in Uttar Pradesh, researchers observed that comprehensive, individualized treatments significantly improved clinical outcomes for South Asian women with PCOS, including reductions in BMI and improvements in insulin sensitivity, ovulation, and pregnancy rates.
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This study evaluated 180 women with Polycystic Ovarian Syndrome (PCOS) in India, revealing significant metabolic and hormonal disruptions. Key findings included a high prevalence of obesity (70%), menstrual irregularities (90%), hirsutism (75%), and insulin resistance (60%). Hormonal imbalances were marked by elevated testosterone and LH levels. Treatment interventions, such as lifestyle modifications, metformin, oral contraceptives, and clomiphene, led to significant improvements in BMI, insulin sensitivity, hyperandrogenic symptoms, ovulation rates, and quality of life. The study emphasizes the importance of individualized, multidisciplinary management strategies to address both metabolic and reproductive aspects of PCOS, particularly in South Asian women.
