Genome Report: Chromosome-Scale Genome Assembly of the African Spiny Mouse (Acomys Cahirinus)

    April 2023 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Elizabeth D. Nguyen, Vahid Nikoonejad Fard, Bernard Kim, Sarah Collins, Miranda Galey, Branden R. Nelson, Paul Wakenight, Simone M. Gable, Aaron McKenna, Theo K. Bammler, Jim MacDonald, Daryl M. Okamura, Jay Shendure, David R. Beier, Jan‐Marino Ramirez, Mark W. Majesky, Kathleen J. Millen, Marc Tollis, Danny E. Miller
    TLDR The improved genome of the African spiny mouse helps study its tissue regeneration.
    The study presents an improved reference genome for the African spiny mouse (Acomys cahirinus), known for its remarkable tissue regeneration abilities. Utilizing long Nanopore sequencing reads, the researchers developed a high-quality genome assembly, which was validated with RNA sequencing data from four different tissues. This enhanced genome is more contiguous and of higher quality than previous versions, providing a valuable resource for further research into the molecular mechanisms underlying the species' regenerative properties.
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