Genome Report: Chromosome-Scale Genome Assembly of the African Spiny Mouse (Acomys Cahirinus)

    April 2023 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Elizabeth D. Nguyen, Vahid Nikoonejad Fard, Bernard Kim, Sarah Collins, Miranda Galey, Branden R. Nelson, Paul Wakenight, Simone M. Gable, Aaron McKenna, Theo K. Bammler, Jim MacDonald, Daryl M. Okamura, Jay Shendure, David R. Beier, Jan‐Marino Ramirez, Mark W. Majesky, Kathleen J. Millen, Marc Tollis, Danny E. Miller
    Studysummary This study presents an improved reference genome for the African spiny mouse, which may aid in understanding its tissue regeneration at the molecular level.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    The study presents an improved reference genome for the African spiny mouse (Acomys cahirinus), a species noted for its remarkable tissue regeneration abilities. Utilizing long Nanopore sequencing reads, the researchers have developed a genome of higher contiguity and quality than previously available versions. The quality of the genome annotations was confirmed using RNA sequencing data from four different tissues. This enhanced genome assembly is expected to aid in the molecular understanding of the regenerative properties of A. cahirinus, facilitating further research in this area.
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