16 citations
,
November 2022 in “American Journal of Clinical Dermatology” 11 citations
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January 2022 in “Experimental Dermatology” This study on central centrifugal cicatricial alopecia (CCCA) suggested that severe, extensive CCCA might be both clinically and biologically distinct from limited disease subtypes. By analyzing tissue samples from women with varying degrees of CCCA, researchers found that severe cases showed increased expression of genes MMP9, SFRP4, and MSR1, which are associated with fibrosis, Wnt signaling, and macrophage-mediated inflammation. These findings indicated that severe CCCA could have a unique gene expression profile, offering potential targets for future research on prognostic markers and therapeutic interventions.
9 citations
,
October 2020 in “Journal of the American Academy of Dermatology” Patients with central centrifugal cicatricial alopecia may have a higher risk of breast and colorectal cancer.
37 citations
,
August 2016 in “Clinical, Cosmetic and Investigational Dermatology” The document concludes that better treatments for CCCA are needed and more research is required to understand its causes related to hairstyling and genetics.
29 citations
,
January 2016 in “International Journal of Dermatology” Longer hair loss leads to more severe CCCA; early treatment and avoiding damaging hairstyles help regrowth.
8 citations
,
September 2015 in “Clinics in Dermatology” Hair loss in children is diagnosed and treated differently than in adults, with different common causes and a focus on less invasive methods.
15 citations
,
November 2012 in “International Journal of Dermatology” The conclusion is that hair loss from CCCA may be genetic and not solely caused by hair grooming practices.
88 citations
,
April 2011 in “Archives of Dermatology” Type 2 diabetes, bacterial scalp infections, and tight hairstyles like braids and weaves are linked to a higher risk of a scarring hair loss condition in African American women.
76 citations
,
November 2010 in “Journal of The American Academy of Dermatology” Some African American women's central scalp hair loss is linked to genetics and past fungal scalp infections, with more research needed on other causes.
25 citations
,
September 2010 in “Journal of Cutaneous Medicine and Surgery” The study found that Central Centrifugal Cicatricial Alopecia mainly affects middle-aged African descent women, is linked to certain hair care practices and genetics, and often goes undiagnosed for years.
72 citations
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July 2008 in “Dermatologic Therapy” CCCA is a scarring hair loss condition mainly in African descent women, possibly caused by genetics and hairstyling, treated with gentle hair care and medications.
