Central Centrifugal Cicatricial Alopecia: A Subtype of Lichen Planopilaris in African Descent?

Central centrifugal cicatricial alopecia (CCCA) is a scarring hair loss condition primarily affecting middle-aged women of African descent, potentially linked to lichen planopilaris (LPP) due to shared clinical and histological features. Genetic mutations, particularly in the PADI3 gene, and possibly hair grooming practices contribute to its pathogenesis. Despite similarities, CCCA exhibits unique trichoscopic findings and less inflammation compared to LPP. The study suggests that CCCA and LPP may exist on a phenotypic spectrum influenced by genetic and environmental factors. Effective management requires early intervention with behavioral changes and anti-inflammatory treatments, though further research is necessary to enhance understanding and therapy.