Development of a Carvedilol-Loaded Solid Self-Nanoemulsifying System with Increased Solubility and Bioavailability Using Mesoporous Silica Nanoparticles

The study developed a carvedilol-loaded solid self-nanoemulsifying drug delivery system (S-SNEDDS) using mesoporous silica nanoparticles (MSN) to enhance the solubility and bioavailability of carvedilol, a poorly soluble drug. The optimal formulation significantly improved carvedilol's solubility by approximately 400 times and dissolution by 5.7 times at 60 minutes compared to the drug alone. Pharmacokinetic studies in rats showed that the S-SNEDDS formulation resulted in a higher maximum plasma concentration (Cmax) and area under the curve (AUC) than carvedilol alone, indicating enhanced bioavailability. The study concludes that MSN can serve as a novel biocompatible carrier, providing a safer and more effective delivery system for poorly soluble drugs.