Formulation and Evaluation of Self-Nanoemulsifying Drug Delivery System for Improved Oral Delivery of Exemestane Hydrochloride

    March 2023 in “ IP International Journal of Comprehensive and Advanced Pharmacology ”
    Bhupendra G. Prajapati, Bhavesh Prajapati, Dignesh Khunt
    TLDR The new drug delivery system improves exemestane's absorption and effectiveness.
    The study developed a self-nanoemulsifying drug delivery system (SNEDDS) to improve the solubility and oral delivery of Exemestane HCl, a poorly water-soluble drug used in breast cancer therapy. The optimized formulations, particularly F3, F7, and F8, demonstrated small droplet sizes and rapid self-emulsification times, with F7 showing no precipitation for up to 24 hours, indicating good stability. The SNEDDS formulation significantly enhanced the dissolution and bioavailability of Exemestane HCl, suggesting it as a promising approach for oral drug delivery.
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