Formulation and Evaluation of Self-Nanoemulsifying Drug Delivery System for Improved Oral Delivery of Exemestane Hydrochloride

    March 2023 in “ IP International Journal of Comprehensive and Advanced Pharmacology ”
    Bhupendra G. Prajapati, Bhavesh Prajapati, Dignesh Khunt
    TLDR The new drug delivery system improves exemestane's absorption and effectiveness.
    The study focuses on improving the solubility and oral delivery of Exemestane HCl (EXM), a steroidal aromatase inhibitor used in breast cancer therapy, by developing a self-nanoemulsifying drug delivery system (SNEDDS). Using a water titration approach, the researchers selected Caprol Microexpress and Labrafac as the oil phase, Tween 80 as the surfactant, and Triacetin as the co-surfactant. Various surfactant:co-surfactant ratios were tested, with Tween 80:Triacetin (1:2) and (1:3) showing the largest nanoemulsion areas. Among 10 formulations, F3, F7, and F8 had the smallest particle sizes and rapid self-emulsification times, with F7 maintaining optical clarity without precipitation for 24 hours. The SNEDDS formulation demonstrated potential for enhanced dissolution and bioavailability of EXM.
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