Exploring the Chorioallantoic Membrane as a Platform for Burn Wound Modeling and Analysis

This study investigates the chicken chorioallantoic membrane (CAM) as a model for burn wound research, emphasizing its ethical advantages and feasibility. The CAM model allows for the creation of standardized burn injuries with a 100% embryonic survival rate, demonstrating rapid wound healing within 72 hours and effective mimicry of key healing processes like re-epithelization and tissue remodeling. Histological analysis confirmed preserved epithelial integrity and vascularization, with no necrosis. The study supports the CAM model as a cost-effective, ethically favorable alternative for pre-clinical burn wound research and therapeutic screening, aligning with the 3Rs principles.