Correlation Between Biochemical and Clinical Hyperandrogenism Parameters in Polycystic Ovary Syndrome in Relation to Age

April 2023 in “ BMC endocrine disorders ”

Zaixin Guo, Fen Jin, Shuwen Chen, Pan Hu, Yanfang Hao, Qi Yu

hyperandrogenism hirsutism free androgen index FAI DHEA DHEA-S DHT alopecia polycystic ovary syndrome PCOS androgenic alopecia

TLDR The link between physical signs of high male hormones and hormone levels in women with PCOS changes with age.

This study examined the correlation between clinical and biochemical hyperandrogenism in 256 women with PCOS, divided into two age groups: 18-29 years and 30-40 years. Younger women showed a significant positive correlation between clinical hyperandrogenism (especially hirsutism) and the free androgen index (FAI), DHEA, and DHEA-S. In contrast, older women had clinical hyperandrogenism influenced more by DHEA, DHEA-S, and DHT, with no significant correlation for alopecia. The study concludes that the relationship between clinical and biochemical hyperandrogenism parameters varies with age, emphasizing the need for age-specific diagnostic and treatment strategies for PCOS.

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Research cited in this study

7 / 7 results

Epidemiology, Diagnosis, and Management of Hirsutism: A Consensus Statement by the Androgen Excess and Polycystic Ovary Syndrome Society

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Experts recommend using evidence-based methods to diagnose and treat hirsutism, focusing on symptoms and underlying causes.

Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline

research Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline

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Polycystic Ovary Syndrome should be seen mainly as a condition of excess male hormones, with a focus on this in its definition.

research Diagnosis of Hyperandrogenism: Clinical Criteria

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The document concludes that hirsutism is the main sign for diagnosing hyperandrogenism, which requires a detailed patient history and physical exam.

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352 citations, January 2006 in “The Journal of Clinical Endocrinology and Metabolism”

Most women referred for excess male hormone symptoms had polycystic ovary syndrome (PCOS), with other conditions being less common.

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169 citations, August 2004 in “Baillière's best practice & research. Clinical obstetrics & gynaecology/Baillière's best practice and research in clinical obstetrics and gynaecology”

Lower doses of treatments for hirsutism and acne in PCOS are effective and cause fewer side effects.

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78 citations, January 2003 in “Dermatology”

Hormonal therapy is becoming a promising treatment for acne.

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Polycystic ovary syndrome is a common hormonal disorder in women, linked to increased risk of metabolic and heart diseases, and needs more research for better understanding and treatment.

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The 2003 consensus updated PCOS diagnosis criteria and highlighted increased risks of diabetes and heart disease for those affected.

Correlation Between Biochemical and Clinical Hyperandrogenism Parameters in Polycystic Ovary Syndrome in Relation to Age

Research cited in this study

research Epidemiology, Diagnosis, and Management of Hirsutism: A Consensus Statement by the Androgen Excess and Polycystic Ovary Syndrome Society

research Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline

research Diagnosis of Hyperandrogenism: Clinical Criteria

research Relative Prevalence of Different Androgen Excess Disorders in 950 Women Referred Because of Clinical Hyperandrogenism

research Hirsutism and Acne in Polycystic Ovary Syndrome

research Update and Future of Hormonal Therapy in Acne

research Classification of the Types of Androgenetic Alopecia (Common Baldness) Occurring in the Female Sex

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