Correlation Between Biochemical and Clinical Hyperandrogenism Parameters in Polycystic Ovary Syndrome in Relation to Age

April 2023 in “ BMC endocrine disorders ”

Zaixin Guo, Fen Jin, Shuwen Chen, Pan Hu, Yanfang Hao, Qi Yu

hyperandrogenism hirsutism free androgen index FAI DHEA DHEA-S DHT alopecia polycystic ovary syndrome PCOS androgenic alopecia

TLDR The link between physical signs of high male hormones and hormone levels in women with PCOS changes with age.

This study examined the correlation between clinical and biochemical hyperandrogenism in 256 women with PCOS, divided into two age groups: 18-29 years and 30-40 years. Younger women showed a significant positive correlation between clinical hyperandrogenism (especially hirsutism) and the free androgen index (FAI), DHEA, and DHEA-S. In contrast, older women had clinical hyperandrogenism influenced more by DHEA, DHEA-S, and DHT, with no significant correlation for alopecia. The study concludes that the relationship between clinical and biochemical hyperandrogenism parameters varies with age, emphasizing the need for age-specific diagnostic and treatment strategies for PCOS.

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