TLDR A girl with Becker's nevus syndrome showed good improvement in breast development using spironolactone.
Becker's nevus syndrome, part of the epidermal nevus syndromes, was described with a phenotype including Becker's nevus, ipsilateral breast hypoplasia, and variable skeletal malformations. It was more frequent in males (5:1) but more relevant in females. Diagnosis was clinically based on the presence of the skin lesion, with no established numbered criteria. Treatment for breast hypoplasia using 50 mg/day of spironolactone, an antiandrogen medication, demonstrated adequate clinical response.
21 citations,
June 2010 in “Anais Brasileiros De Dermatologia” The document reports the first Brazilian case of a girl with Becker nevus syndrome, characterized by skin changes, breast underdevelopment, and scoliosis.
29 citations,
February 2003 in “Journal of Dermatology” Spironolactone may help enlarge a small breast linked to Becker's nevus.
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7 citations,
January 2016 in “Case reports in pediatrics” A girl with Becker's nevus syndrome showed good improvement in breast development using spironolactone.
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165 citations,
February 1994 in “Fertility and Sterility” Flutamide is more effective and has fewer side effects than spironolactone for treating hirsutism.
26 citations,
January 1994 in “Hormone and Metabolic Research” Taking spironolactone and linestrenol for androgen excess can lead to lower bone density in young women.
