Coexistence of a Basal Cell Carcinoma and Leiomyosarcoma: An Unusual Collision Tumor

March 2019 in “ American Journal of Dermatopathology ”

Duygu Gülseren, Mary Margaret Noland, Alejandro A. Gru

basal cell carcinoma cutaneous leiomyosarcoma non-melanoma skin cancer mesenchymal tumor platelet-derived growth factor tumor microenvironment BCC LMS PDGF

TLDR Recognizing rare tumor combinations is crucial for accurate diagnosis and treatment.

This document reported a unique case of a collision tumor consisting of basal cell carcinoma (BCC) and cutaneous leiomyosarcoma (LMS) in a 63-year-old woman. BCC is a common skin cancer, while LMS is less common and can metastasize, requiring surgical intervention. The study highlighted the potential role of the tumor microenvironment, including platelet-derived growth factor (PDGF) and fibroblasts, in the development of such tumors. The authors suggested that pathologists should be aware of the coexistence of BCC and LMS, as it may have implications for diagnosis and treatment.

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Research cited in this study

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research Epithelial-Stromal Interactions in Basal Cell Cancer: The PDGF System

91 citations , March 1994 in “Journal of Investigative Dermatology”

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745 citations , February 1992 in “Trends in genetics”

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