Coexistence of a Basal Cell Carcinoma and Leiomyosarcoma: An Unusual Collision Tumor

March 2019 in “ American Journal of Dermatopathology ”

Duygu Gülseren, Mary Margaret Noland, Alejandro A. Gru

basal cell carcinoma cutaneous leiomyosarcoma non-melanoma skin cancer mesenchymal tumor platelet-derived growth factor tumor microenvironment BCC LMS PDGF

TLDR Recognizing rare tumor combinations is crucial for accurate diagnosis and treatment.

This document reported a unique case of a collision tumor comprising basal cell carcinoma (BCC) and cutaneous leiomyosarcoma (LMS) in a 63-year-old woman. BCC is a common non-melanoma skin cancer, while LMS is a rare mesenchymal tumor that can metastasize. The study highlighted the histopathological findings and immunohistochemical features that led to the diagnosis. It discussed the potential mechanisms behind the coexistence of these tumors, including the role of platelet-derived growth factor (PDGF) and the tumor microenvironment in promoting mesenchymal overgrowth. The document emphasized the importance of recognizing such unusual tumor combinations for accurate diagnosis and treatment planning.

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Research cited in this study

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research Epithelial-Stromal Interactions in Basal Cell Cancer: The PDGF System

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