Continued Treatment With Baricitinib Results in Meaningful Scalp Responses Among Scalp Non-Responder Patients With Eyebrow/Eyelash Regrowth in the First Year

    November 2024 in “ Journal of the European Academy of Dermatology and Venereology ”
    Arash Mostaghimi, Matthias Augustin, Kazutoshi Harada, Maryanne M. Senna, Yves Dutronc, Guanglei Yu, Susan Ball, Mwangi J. Murage, Jill Kolodsick, Yiying Brogan, Brett King
    Image of study
    TLDR Long-term baricitinib treatment can lead to significant scalp hair regrowth in patients initially showing only eyebrow or eyelash regrowth.
    The study investigates the long-term effects of baricitinib, a JAK 1 and 2 inhibitor, on patients with severe alopecia areata (AA) who initially showed eyebrow or eyelash regrowth but not significant scalp hair regrowth within the first year. In the BRAVE trials, 78 out of 515 patients treated with 4 mg of baricitinib experienced eyebrow/eyelash regrowth but not a SALT score ≤20 at Week 52. By Week 104, 39% of these patients achieved a SALT score ≤20, indicating significant scalp hair regrowth, which was maintained through Week 152. The study highlights that eyebrow or eyelash regrowth can precede scalp hair regrowth, especially in patients with more severe baseline conditions, suggesting that longer treatment durations may be necessary for optimal outcomes.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 11 results

      community What else is good. Besides the big 3.

      in Chat  36 upvotes 1 month ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 2 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

      community Should I get transplant #4 or just shave my head?

      in Transplants  172 upvotes 3 months ago
      A 36-year-old considering a fourth hair transplant is advised to either shave his head or use a hair system due to poor results from previous transplants and late medication use. He plans to consult top surgeons and adjust his current treatments, including finasteride and minoxidil.

      community Olumiant active ingredient Baricitinib

      in Research/Science  1 upvotes 1 year ago
      The conversation is about someone inquiring if anyone has tried Olumiant or its active ingredient, Baricitinib, for hair loss, mentioning the cost and that they have ordered Baricitinib.

    Related Research

    2 / 2 results