Baricitinib in Pediatric Chronic Immune Thrombocytopenia and Associated Autoimmune Conditions: A Case Report

December 2024 in “ Frontiers in Pediatrics ”

G. López de Hontanar Torres, Josune Zubicaray, Elena Sebastián, Á. Hernández‐Martín, June Iriondo, Julián Sevilla

baricitinib JAK 1/2 inhibitor alopecia areata

TLDR Baricitinib improved platelet counts and alopecia in a 16-year-old with chronic immune thrombocytopenia.

This case report highlights the successful use of baricitinib, a JAK 1/2 inhibitor, in a 16-year-old female with chronic immune thrombocytopenia (cITP) and alopecia areata, where conventional treatments failed. Baricitinib, used off-label, significantly improved platelet counts and alopecia, with sustained normal platelet levels post-treatment. The findings suggest baricitinib as a potential treatment for pediatric cITP with autoimmune conditions, warranting further clinical trials to validate its efficacy.

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Research cited in this study

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research Two Phase 3 Trials of Baricitinib for Alopecia Areata

148 citations, March 2022 in “The New England Journal of Medicine”

Baricitinib was effective in treating alopecia areata in two major trials.

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6 / 12 results

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 4 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community What else is good. Besides the big 3.

in Chat 34 upvotes 5 months ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

community I am a dermatologist with a clinical interest in alopecia. AMA

in Will treatment work for me? 2 years ago

In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

community Should I get transplant #4 or just shave my head?

in Transplants 170 upvotes 7 months ago

A 36-year-old considering a fourth hair transplant is advised to either shave his head or use a hair system due to poor results from previous transplants and late medication use. He plans to consult top surgeons and adjust his current treatments, including finasteride and minoxidil.

community What are the odds baricitinib will get a topical otc version for androgenic alopecia?

in Research/Science 2 years ago

Baricitinib, approved for alopecia areata, might be considered for treating receding hairlines. The discussion is about the possibility of an over-the-counter topical version for androgenic alopecia.

community Anyone heard of or have experience using baricitinib?

in Research/Science 1 upvotes 1 year ago

The conversation is about baricitinib, a medicine that can help with hair loss, and why it isn't more popular or widely discussed. No specific experiences with the treatment were shared.

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6 / 439 results

Safety of Janus Kinase Inhibitors in Patients with Alopecia Areata: A Systematic Review

Baricitinib in Pediatric Chronic Immune Thrombocytopenia and Associated Autoimmune Conditions: A Case Report

Research cited in this study

research Two Phase 3 Trials of Baricitinib for Alopecia Areata

Related Community Posts Join

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community What else is good. Besides the big 3.

community I am a dermatologist with a clinical interest in alopecia. AMA

community Should I get transplant #4 or just shave my head?

community What are the odds baricitinib will get a topical otc version for androgenic alopecia?

community Anyone heard of or have experience using baricitinib?

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