Windows Azure Hyper-V Recovery Manager Is Now in General Availability

January 2014 in “ www.virtualization.info ”

Marcel van den Berg

MED1 keratinocytes follistatin MAPK pathway hair follicle stem cells

TLDR MED1 affects skin wound healing differently with age, speeding it up in young mice but slowing it in older mice.

The study investigated the role of MED1 in skin wound healing using keratinocyte-specific MED1 null mice (Med1(epi-/-)). In 8-week-old Med1(epi-/-) mice, wound healing was accelerated compared to wild-type mice, with increased epithelial migration and cell proliferation, linked to decreased follistatin expression and enhanced MAPK pathway activity. However, in 6-month-old Med1(epi-/-) mice, wound healing was delayed, with reduced cell proliferation and hair follicle stem cell contribution, suggesting age-related differences in MED1's role. The findings highlighted MED1's novel function in keratinocytes and its potential as a therapeutic target for skin wound healing and aging.

View this study on virtualization.info →

Discuss this study in the Community →

Similar Research

5 / 114 results

research Alteration of Skin Wound Healing in Keratinocyte-Specific Mediator Complex Subunit 1 Null Mice

20 citations , August 2014 in “PloS one”

MED1 affects skin wound healing differently in young and old mice.

research Roles of MED1 in Quiescence of Hair Follicle Stem Cells and Maintenance of Normal Hair Cycling

16 citations , August 2012 in “The journal of investigative dermatology/Journal of investigative dermatology”

MED1 is essential for normal hair growth and maintaining hair follicle stem cells.

research Mutant Laboratory Mice With Abnormalities in Hair Follicle Morphogenesis, Cycling, and Structure: An Update

52 citations , October 2012 in “Journal of Dermatological Science”

The document concludes that mouse models are crucial for studying hair biology and that all mutant mice may have hair growth abnormalities that require detailed analysis to identify.

An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities

research An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities

23 citations , December 2020 in “Frontiers in Cell and Developmental Biology”

Gene network oscillations inside hair stem cells are key for hair growth regulation and could help treat hair loss.

research Epidermal Stem Cell Diversity and Quiescence

168 citations , August 2009 in “EMBO molecular medicine”

Epidermal stem cells are diverse and vary in activity, playing key roles in skin maintenance and repair.