An Autopsy Case of Unicentric Castleman's Disease Associated with Bronchiolitis Obliterans

    July 2014 in “ Respirology Case Reports ”
    Koichi Kobayashi, Nobuharu Ohshima, Masahiro Shimada, Masahiro Kawashima, Hirotoshi Matsui, Akira Hebisawa
    TLDR A woman with Castleman's disease died from respiratory failure due to bronchiolitis obliterans.
    A 34-year-old woman with unicentric Castleman's disease experienced enanthema, hair loss, and a nonproductive cough. Despite corticosteroid treatment, her symptoms persisted, and she developed progressive dyspnea. Diagnosed with bronchiolitis obliterans, she died from respiratory failure. Autopsy revealed constrictive bronchiolitis, nonviral chronic hepatitis, and interstitial nephritis, confirming paraneoplastic autoimmune multiorgan syndrome. This case highlighted the lethally progressive nature of constrictive bronchiolitis associated with Castleman's disease, emphasizing the need for early detection and treatment.
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