Expressions and Effects of Autophagy-Related Genes in Bleomycin-Induced Skin Fibrosis of Mice
May 2020
in “
PubMed
”
New to collagen? There is a guide in the encyclopedia. Read the guide → Studysummary This study found that autophagy-related gene expressions in bleomycin-induced mouse skin fibrosis initially increased and then decreased, implying autophagy activation may potentially reverse skin fibrosis. Our plain-language summary of this paper — not a Tressless recommendation.
The study on 72 male BALB/c mice examined the impact of autophagy-related genes on bleomycin-induced skin fibrosis. Bleomycin significantly increased skin thickness and collagen disorder while reducing hair follicle numbers. Initially, the expression of autophagy-related genes such as p62, LC3 Ⅱ, and Beclin-1 increased but later decreased, indicating that autophagy activation might reverse skin fibrosis. The research suggested that autophagy had a dynamic role in the progression of bleomycin-induced skin fibrosis.
