Expressions and Effects of Autophagy-Related Genes in Bleomycin-Induced Skin Fibrosis of Mice

May 2020 in “ PubMed ”

Xijing He, J Li, J Q Liu, Zhe Zheng, Di Hu

autophagy bleomycin skin fibrosis collagen hair follicles p62 LC3 Ⅱ Beclin-1

TLDR Activating autophagy might reverse skin fibrosis.

The study investigated the role of autophagy-related genes in bleomycin-induced skin fibrosis in 72 male BALB/c mice. The results showed that skin fibrosis was characterized by increased skin thickness, disordered collagen, and reduced hair follicles in the bleomycin group compared to controls. Autophagy-related genes, including p62, LC3 Ⅱ, and Beclin-1, initially increased and then decreased during the fibrosis process. The findings suggested that activating autophagy could potentially reverse skin fibrosis, highlighting the dynamic expression of autophagy-related genes in response to bleomycin stimulation.

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research Expressions and Effects of Autophagy-Related Genes in Bleomycin-Induced Skin Fibrosis of Mice

1 citations , May 2020 in “PubMed”

Activating autophagy might reverse skin fibrosis.