Expressions and Effects of Autophagy-Related Genes in Bleomycin-Induced Skin Fibrosis of Mice

    May 2020 in “ PubMed ”
    Xijing He, J Li, J Q Liu, Zhe Zheng, Di Hu
    TLDR Activating autophagy might reverse skin fibrosis.
    The study on 72 male BALB/c mice examined the impact of autophagy-related genes on bleomycin-induced skin fibrosis. Bleomycin significantly increased skin thickness and collagen disorder while reducing hair follicle numbers. Initially, the expression of autophagy-related genes such as p62, LC3 Ⅱ, and Beclin-1 increased but later decreased, indicating that autophagy activation might reverse skin fibrosis. The research suggested that autophagy had a dynamic role in the progression of bleomycin-induced skin fibrosis.
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