Chronic Exposures to the Herbicide Atrazine and the Pharmaceutical Finasteride Disrupt Sex Steroid and Thyroid Hormone Signaling and Gonadal Development in Frogs

January 2010 in “ uO Research (University of Ottawa) ”

Valérie S. Langlois

finasteride atrazine sex steroid thyroid hormone gonadal development srd5alpha srd5beta endocrine-disrupting chemicals Propecia

TLDR Atrazine and finasteride disrupt hormone signaling and affect frog development.

This research investigated the effects of the herbicide atrazine and the pharmaceutical finasteride on frog development. Atrazine exposure in Northern leopard frog tadpoles led to reduced metamorphic success, a female-biased sex ratio, and altered hormone-related enzyme activities. Finasteride exposure in Western clawed frogs inhibited certain enzyme activities and induced testicular oocytes in males, indicating an intersex condition. The study highlighted that both atrazine and finasteride disrupted sex steroid and thyroid hormone signaling, affecting gonadal development. These findings suggested that the enzymes srd5alpha and srd5beta are crucial during frog development and are potential targets for endocrine-disrupting chemicals.

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