Asymmetric Adhesive SIS-Based Wound Dressings for Therapeutically Targeting Wound Repair

    January 2024 in “ Journal of Nanobiotechnology ”
    Wende Yao, Zelong Song, Xiaodong Ma, Yiqian Huang, Xueying Zhang, Yunhuan Li, Pengfei Wei, Julei Zhang, Chenlu Xiong, Sihan Yang, Yujian Xu, Jing Wei, Bo Zhao, Xuesong Zhang, Yan Han
    TLDR The new wound dressing improves healing and tissue repair better than conventional dressings.
    The study developed an asymmetric adhesive wound dressing, SIS/PAA/LAP, which outperformed conventional dressings like Tegaderm in terms of tissue adhesion strength (~33 kPa) and burst strength (~22 kPa). It maintained high cell viability (~95% with L929 fibroblasts) and demonstrated strong angiogenic capacity. In animal models with full-thickness skin injuries in rats and Bama miniature pigs, the dressing accelerated tissue vascularization and improved tissue repair outcomes. The release of bioactive ions such as Mg2+ and Si4+ facilitated cell migration, proliferation, and angiogenesis. These findings suggest that the SIS-based patch is a promising candidate for wound care, hernia repair, and cardiovascular stents.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 32 results

      community Still receding at 8 months on finasteride?

      in Finasteride/Dutasteride  21 upvotes 4 months ago
      The user has been using oral finasteride, oral minoxidil, topical minoxidil, and microneedling to address hair loss but continues to experience recession after 8 months. Suggestions include being patient as treatments can take 12-18 months to show effects, considering a switch to dutasteride, and consulting a dermatologist for potential underlying scalp conditions.

      community I think I’ve finally found the reason for my hair loss

      in Chat  98 upvotes 1 year ago
      The user experienced hair loss since 2019 and tried finasteride, dutasteride, RU58841, and ketoconazole shampoo without success. A scalp biopsy showed scarring and inflammation from folliculitis, indicating chronic inflammation was affecting treatment effectiveness.

      community 8.5 month transplant + meds update - 2,689 grafts

      in Transplants  382 upvotes 2 years ago
      Ibrox1972 shared an 8.5-month update on their 2,689-graft hair transplant by Dr. Raghu Reddy in London, along with using oral finasteride, oral minoxidil, and microneedling. Users praised the natural-looking results and discussed the importance of choosing a skilled doctor.

      community Estenove Transplant Review From NYC Guy Mid 20s

      in Transplants  1 upvotes 6 months ago
      The user had a hair transplant with Estenove, rating the overall experience 6/10 due to logistical issues, unmet expectations, and dissatisfaction with the results. They advise against pricier packages and express regret over the asymmetrical hairline, despite good customer service and post-op care.

    Related Research

    1 / 1 results