Asymmetric Adhesive SIS-Based Wound Dressings for Therapeutically Targeting Wound Repair

    January 2024 in “ Journal of Nanobiotechnology ”
    Wende Yao, Zelong Song, Xiaodong Ma, Yiqian Huang, Xueying Zhang, Yunhuan Li, Pengfei Wei, Julei Zhang, Chenlu Xiong, Sihan Yang, Yujian Xu, Jing Wei, Bo Zhao, Xuesong Zhang, Yan Han
    TLDR The new wound dressing improves healing and tissue repair better than conventional dressings.
    The study introduces an innovative asymmetric adhesive wound dressing, SIS/PAA/LAP, designed to enhance tissue regeneration and improve healing outcomes. This dressing, developed from acrylate acid solution with laponite nanoparticles and photo-crosslinked on a small intestinal submucosa patch, demonstrated superior tissue adhesion (~33 kPa) and burst strength (~22 kPa) compared to conventional dressings. It maintained cell viability and showed strong angiogenic capacity. In animal models, including rats and Bama miniature pigs, the dressing effectively accelerated tissue vascularization and improved repair outcomes, indicating its potential for advanced wound care applications.
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