Asymmetric Adhesive SIS-Based Wound Dressings for Therapeutically Targeting Wound Repair

January 2024 in “ Journal of Nanobiotechnology ”

Wende Yao, Zelong Song, Xiaodong Ma, Yiqian Huang, Xueying Zhang, Yunhuan Li, Pengfei Wei, Julei Zhang, Chenlu Xiong, Sihan Yang, Yujian Xu, Jing Wei, Bo Zhao, Xuesong Zhang, Yan Han

asymmetric adhesive wound dressing SIS/PAA/LAP acrylate acid laponite nanoparticles photo-crosslinked small intestinal submucosa tissue regeneration angiogenic capacity vascularization

TLDR The new wound dressing improves healing and tissue repair better than conventional dressings.

The study developed an asymmetric adhesive wound dressing, SIS/PAA/LAP, which outperformed conventional dressings like Tegaderm in terms of tissue adhesion strength (~33 kPa) and burst strength (~22 kPa). It maintained high cell viability (~95% with L929 fibroblasts) and demonstrated strong angiogenic capacity. In animal models with full-thickness skin injuries in rats and Bama miniature pigs, the dressing accelerated tissue vascularization and improved tissue repair outcomes. The release of bioactive ions such as Mg2+ and Si4+ facilitated cell migration, proliferation, and angiogenesis. These findings suggest that the SIS-based patch is a promising candidate for wound care, hernia repair, and cardiovascular stents.

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Research cited in this study

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research Strontium Zinc Silicate Bioceramic Composite Electrospun Fiber Membrane for Hair Follicle Regeneration in Burn Wounds

1 citations , August 2023 in “Composites Part B: Engineering”

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