Apremilast for Extensive and Treatment-Resistant Alopecia Areata: A Retrospective Analysis of Five Patients

    April 2020 in “ European Journal of Dermatology ”
    Benedikt Weber, Sonja Radaković, Adrian Tanew
    Studysummary This study found that apremilast treatment did not result in sustained improvement for most patients with treatment-resistant alopecia areata, although one patient experienced significant benefit.
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    Research cited in this study 14

    1. Efficacy of the Phosphodiesterase-4 Inhibitor, Apremilast, in a Patient with Severe Alopecia Areata European Journal of Dermatology · 2019
    2. Apremilast Is Efficacious in Refractory Alopecia Areata Journal of dermatological treatment · 2019
    3. A Randomized Placebo-Controlled Single-Center Pilot Study of the Safety and Efficacy of Apremilast in Subjects with Moderate-to-Severe Alopecia Areata Archives of dermatological research · 2018
    4. Lack of Efficacy of Apremilast in 9 Patients with Severe Alopecia Areata Journal of the American Academy of Dermatology · 2017
    5. The Changing Landscape of Alopecia Areata: The Therapeutic Paradigm Advances in Therapy · 2017
    6. A Novel Therapeutic Paradigm for Patients with Extensive Alopecia Areata Expert Opinion on Biological Therapy · 2016
    7. Extensive Alopecia Areata Is Reversed by IL-12/IL-23p40 Cytokine Antagonism The Journal of Allergy and Clinical Immunology · 2015
    8. Alopecia Areata Profiling Shows TH1, TH2, and IL-23 Cytokine Activation Without Parallel TH17/TH22 Skewing ˆThe ‰journal of allergy and clinical immunology/Journal of allergy and clinical immunology/˜The œjournal of allergy and clinical immunology · 2015
    9. The PDE4 Inhibitor, Apremilast, Suppresses Experimentally Induced Alopecia Areata in Human Skin In Vivo Journal of Dermatological Science · 2014
    10. The Effect of Oral Cyclosporine in the Treatment of Severe Alopecia Areata Cutaneous and ocular toxicology · 2013
    11. Systemic Treatment for Alopecia Areata Dermatologic therapy · 2011
    12. Alopecia Areata: Clinical Presentation, Diagnosis, and Unusual Cases Dermatologic Therapy · 2011
    13. Alopecia Areata Update Journal of The American Academy of Dermatology · 2010
    14. A Comparison of the Efficacy, Relapse Rate, and Side Effects Among Three Modalities of Systemic Corticosteroid Therapy for Alopecia Areata Dermatology · 2006

    Related research 2

    1. Comparing the Efficacy of Oral Apremilast, Intralesional Corticosteroids, and Their Combination in Patients With Patchy Alopecia Areata: A Randomized Clinical Controlled Trial Archives of Dermatological Research · 2024
    2. Twenty Nail Dystrophy with Alopecia Areata in an Atopic Child International journal of research in dermatology · 2019