An Apple Stem Cell-Derived Extract Increases Epithelial Stem Cells Number in the Hair Follicle Bulge
September 2019
in “
Journal of Investigative Dermatology
”
apple stem cell extract ACE K15+ hair follicle bulge stem cells hair follicle elongation hair matrix keratinocyte proliferation anagen to catagen switch hair follicle epithelial stem cell marker K15 hair follicle bulge stem cells hair follicle aging hair loss disorders K15+ cells hair growth hair loss
TLDR Apple stem cell extract may increase the number of stem cells in a part of the hair follicle.
In 2019, a study was conducted to investigate the impact of an apple stem cell extract (ACE) on human hair follicle biology, specifically on K15+ hair follicle bulge stem cells. The study used full-length hair follicles from two healthy donors and treated them with 0.1% and 0.3% ACE. The results showed that neither concentration was cytotoxic and did not significantly affect hair follicle elongation, hair matrix keratinocyte proliferation and apoptosis, or the anagen to catagen switch. However, 0.3% ACE did increase the expression of the hair follicle epithelial stem cell marker K15 and significantly up-regulated the number of K15+ cells in the bulge. This suggests that ACE specifically targets and influences hair follicle bulge stem cells biology, potentially useful in cosmetic formulations to reverse the reduction of bulge stem cells number reported in skin and hair follicle aging/senescence and hair loss disorders.
