Antiexudative Effects of Finasteride and a New Pyrazolo[C]Pyridine Derivative GIZh-72 in Acetic Acid-Induced Experimental Peritonitis

    February 2020 in “ Bulletin of Experimental Biology and Medicine ”
    N V Kudryashov, Ekaterina Ivanova, Tatyana S. Kalinina, Alexander Shimshirt, A A Kurshin, L. A. Zhmurenko, T. A. Voronina
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    TLDR Finasteride and GIZh-72 reduce inflammation, with GIZh-72 being more effective.
    A study conducted on rodents found that both finasteride and a new pyrazolo[C]pyridine derivative called GIZh-72 had anti-inflammatory effects in mice with induced peritonitis. GIZh-72 was found to be more effective than finasteride, indicating its potential as a therapeutic agent for peritonitis. Finasteride also had analgesic effects and enhanced the analgesic effect of morphine in rodents. The study suggests that both finasteride and GIZh-72 have potential therapeutic applications in inflammatory diseases. However, further research is needed to confirm these findings.
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