Prevalence of Anti-Thyroid Peroxidase Antibodies Among Women With Polycystic Ovary Syndrome
September 2025
in “
Scientific Reports
”
TLDR Women with PCOS are more likely to have thyroid antibodies than those without.
This study investigated the prevalence of autoimmune thyroid disease (AITD) in women with polycystic ovary syndrome (PCOS) compared to age-matched controls, involving 1047 women with PCOS and 1047 controls. Women with PCOS had significantly higher serum anti-thyroid peroxidase antibody (anti-TPO Ab) levels than controls, with 12.89% of PCOS patients testing positive for anti-TPO antibodies. The study found that higher BMI and AMH levels were associated with lower odds of anti-TPO positivity. Although no significant difference in serum thyroid-stimulating hormone (TSH) concentrations was observed, TSH tended to be higher in PCOS patients. These results highlight the importance of screening for anti-TPO antibodies and assessing TSH in PCOS patients, suggesting a potential link between PCOS and thyroid dysfunction.
