Angiogenic factor-driven improvement of refractory thin endometrium with autologous platelet-rich plasma intrauterine infusion in frozen embryo transfer cycles

This study involved 91 patients and demonstrated that intrauterine platelet-rich plasma (PRP) infusion significantly improved outcomes for those with refractory thin endometrium and repeated IVF failures. PRP treatment increased live birth rates to 20.9% and implantation rates to 16.4%, with an average endometrial thickness increase of 0.8 mm, compared to previous cycles without PRP. The improvements are attributed to angiogenic cytokines in PRP, such as Ang-1, EGF, and PDGF, which enhance endometrial receptivity. No adverse effects were reported, suggesting PRP as a promising treatment for improving pregnancy outcomes, though further research is needed to confirm these findings and optimize protocols.