Recurrent Implantation Failure: A Comprehensive Summary from Etiology to Treatment

January 2023 in “ Frontiers in Endocrinology ”

Junying Ma, Wenyan Gao, Da Li

recurrent implantation failure uterine natural killer cells immune tolerance angiogenesis thrombophilias fibroids endometriosis intralipid therapy lymphocyte immunization anticoagulants platelet-rich plasma granulocyte colony-stimulating factor chronic endometritis RIF uNK cells PRP G-CSF

TLDR Individualized treatment and support can help most couples with recurrent implantation failure achieve pregnancy.

Recurrent implantation failure (RIF) is a complex condition characterized by the failure to achieve pregnancy after transferring at least three good-quality embryos in women under 40. The document explores various risk factors, including high BMI, smoking, alcohol, and stress, and highlights the role of uterine natural killer (uNK) cells in maternal-fetal immune tolerance and angiogenesis. Imbalances in immune cells, thrombophilias, and anatomical abnormalities like fibroids and endometriosis are also discussed. Treatment strategies include lifestyle changes, medical interventions, and therapies like intralipid therapy, lymphocyte immunization, and anticoagulants. Promising treatments such as platelet-rich plasma (PRP), granulocyte colony-stimulating factor (G-CSF), and antibiotics for chronic endometritis are noted, but further research is needed to establish effective protocols.

View this study on frontiersin.org →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

research Autologous Platelet-Rich Plasma Improves Endometrial Thickness and Live Birth Rate in Patients with Recurrent Implantation Failure and Thin Endometrium

44 citations , May 2022 in “Journal of Assisted Reproduction and Genetics”

research Systematic Review of Platelet-Rich Plasma (PRP) Preparation and Composition for the Treatment of Androgenetic Alopecia

37 citations , May 2018 in “Journal of Cosmetic Dermatology”

PRP shows promise for hair loss treatment, but needs standardized preparation and composition.

research A Mechanistic Model of Platelet-Rich Plasma Treatment for Androgenetic Alopecia

60 citations , September 2016 in “Dermatologic Surgery”

PRP treatment may stimulate hair growth by promoting blood vessel formation, increasing growth factors, and preventing cell death.

Related Community Posts Join

6 / 73 results

community If we can clone a sheep why we can't cure baldness till now

in Research/Science 181 upvotes 4 months ago

Hair loss treatments like Minoxidil, finasteride, and stem cell therapies exist, but a complete cure is hindered by genetic complexity and market dynamics. Cloning hair follicles is considered a potential solution, but it's currently not feasible.

community How bad is it ? Losing ground

in Journals / Progress Pictures 19 upvotes 9 months ago

The user is considering using dutasteride or finasteride for hair loss and has recurrent folliculitis. Another user suggests treating the folliculitis and notes diffuse thinning.

community 2 years of treatment with fin, dut and oral minoxidil

in Progress Pictures 6 upvotes 2 weeks ago

The user experienced chronic telogen effluvium and mild male pattern baldness, treated with finasteride, oral minoxidil, and later switched to dutasteride, which stopped excessive hair shedding. Other treatments like low-level laser therapy, hair loss shampoos (except ketoconazole), and supplements were ineffective.

community Experiencing a ton of hair loss after three years on Fin. Is this normal?

in Finasteride/Dutasteride 10 upvotes 6 months ago

The user experienced significant hair loss after three years on finasteride, possibly due to inconsistent use, stress, or a cyclical shed. Suggestions included using reminders for consistent medication intake, considering dutasteride, and addressing stress factors.

community Why am I significantly losing ground even though I am constantly adding to my stack?

in Is this regrowth? 18 upvotes 2 years ago

The user is experiencing significant hair loss despite using treatments like finasteride, minoxidil, dutasteride, micro-needling, rosemary oil, and various vitamins. In the conversation, others suggest checking iron and hemoglobin levels, maintaining a positive attitude, and adding RU58841 to the treatment regimen.

community Anyone here going the “natural” route?

in Scalp Massage 48 upvotes 3 years ago

People discussing their experiences with natural treatments for hair loss, such as essential oils, deep scalp massages, anti-inflammatory measures, and supplements. Most of the replies suggest that these treatments are not effective and recommend medication such as minoxidil or finasteride instead.

Similar Research

5 / 1000+ results

research Immunological and Metabolic Causes of Infertility in Polycystic Ovary Syndrome

3 citations , May 2023 in “Biomedicines”

PCOS causes infertility mainly due to hormonal imbalances, insulin resistance, and chronic inflammation.

research Obesity and Peri-Implantation Endometrium

August 2014 in “Warwick Research Archive Portal (University of Warwick)”

Obesity negatively affects the endometrium, leading to higher miscarriage risk and impaired cell function.

ESGCT and FSGT Collaborative Congress Helsinki, Finland September 17–20, 2015 Abstracts