Androgens and Parkinson’s disease: the role in humans and in experiment

September 2022 in “ Problems of Endocrinology ”

Aida U. Hamadyanova, К.О. Кузнецов, E. I. Gaifullina, D. A. Kalandin, R. R. Khamidullina, I. F. Khalitova, R. M. Faizov, N. O. Kamaletdinova, B. F. Aslanova, A. G. Nakieva, L. E. Burangulova, G. O. Gaisina

androgens 5α-reductase inhibitors dutasteride dopamine neurons sex hormones Avodart

TLDR Dutasteride shows promise as a potential treatment for Parkinson's disease.

The article reviewed the role of androgens in Parkinson's disease (PD), noting that PD was more prevalent in men, suggesting a link with sex hormones. Despite the availability of drugs targeting androgen pathways, none had proven effective for PD treatment. While 5α-reductase inhibitors showed potential neuroprotective and anti-dyskinetic effects, further research was needed. Dutasteride, in particular, demonstrated neuroprotective effects before damage to dopamine neurons and was considered promising for its anti-dyskinetic properties without negative effects, making it a potential treatment option for PD patients.

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Research cited in this study

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