Androgen responsive genes as they affect hair growth.

August 2001 in “ PubMed ”

Marty E. Sawaya, Robert W. Keane, Ulrike Blume‐Peytavi, Diane Mullins, Bernard P. Nusbaum, David Whiting, Donald W. Nicholson

TLDR Finasteride reduces caspase levels, helping hair growth in AGA patients.

The study investigated the role of caspases in hair follicles of men with androgenetic alopecia (AGA) and the effect of finasteride treatment. It found that caspases, particularly caspase 3, were more highly expressed in AGA patients compared to those with normal scalps, suggesting a link to increased apoptosis in hair follicles. After 6 months of treatment with 1 mg oral finasteride, the expression levels of these caspases in AGA patients decreased to levels similar to those in the normal group. The study concluded that dihydrotestosterone (DHT) might regulate caspase genes, influencing programmed cell death and affecting the hair growth cycle.

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