Androgen receptor (AR) gene (CAG)n and (GGN)n length polymorphisms and symptoms in young males with long-lasting adverse effects after finasteride use against androgenic alopecia

The study explored whether certain gene polymorphisms in the androgen receptor (AR) gene are implicated in Post-Finasteride Syndrome (PFS), which are long-term adverse symptoms experienced by men who used finasteride as an oral drug against androgenic alopecia (AGA). The study found that the short and/or long (CAG)n and (GGN)n repeats had different frequencies according to symptoms experienced by PFS patients, likely reflecting the vast array of genes modulated by the AR. The study also found a U-curvilinear profile of (CAG)n repeats for skin dryness symptom, where both extremes had a worse condition than medium repeats. Further studies are needed to investigate the PFS pathophysiology using a precision medicine approach.