Analysis of hairless corepressor mutants to characterize molecular cooperation with the vitamin D receptor in promoting the mammalian hair cycle
April 2010
in “
Journal of Cellular Biochemistry
”
Research cited in this study
15 / 15 resultsresearch Modulation of Vitamin D Receptor Activity by the Corepressor Hairless: Differential Effects of Hairless Isoforms
research Quantification of the Vitamin D Receptor-Coregulator Interaction
Vitamin D receptor binds similarly to natural and synthetic ligands, affecting gene regulation.
research The “Bald Mill Hill” Mutation in the Mouse Is Associated with an Abnormal, Mislocalized HR bmh Protein
research Interactions of the Vitamin D Receptor with the Corepressor Hairless
Most Hairless gene mutations reduce its ability to work with the Vitamin D Receptor, which might explain a certain type of hair loss.
research A novel missense mutation in the mouse hairless gene causes irreversible hair loss: Genetic and molecular analyses of Hrm1Enu
research Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes
Hairless protein can block vitamin D activation in skin cells.
research Ligand-Independent Actions of the Vitamin D Receptor Maintain Hair Follicle Homeostasis
research Hereditary 1,25-Dihydroxyvitamin D Resistant Rickets Due to a Mutation Causing Multiple Defects in Vitamin D Receptor Function
A specific gene mutation causes vitamin D resistance, but certain vitamin D analogs might help.
research Physical And Functional Interaction Between The Vitamin D Receptor And Hairless Corepressor, Two Proteins Required For Hair Cycling
Vitamin D receptor and hairless protein are essential for hair growth.
research Atrichia with papular lesions resulting from a novel homozygous missense mutation in the hairless gene
Atrichia with papular lesions (APL) was identified as a rare autosomal recessive disorder characterized by complete and irreversible hair loss shortly after birth, along with the development of papular lesions of keratin-filled follicular cysts. This study reported a novel missense mutation, E583V, in the hairless gene in an Italian family affected by APL. The mutation was located between the LXXLL motif in exon 5 and the zinc-finger motif in exon 6, regions that were highly conserved across several species. This finding contributed to the understanding of the critical role of these domains in the function of the hairless protein and highlighted the occurrence of APL in small, non-consanguineous families globally.
research A Novel Missense Mutation Affecting the Human Hairless Thyroid Receptor Interacting Domain 2 Causes Congenital Atrichia
A specific gene mutation causes congenital hair loss.
research The Hairless Gene in Androgenetic Alopecia: Results of a Systematic Mutation Screening and a Family-Based Association Approach
Hairless gene not strongly linked to baldness.