Comparison of Different Alpha-Blocker Combinations in Male Hypertensives with Refractory Lower Urinary Tract Symptoms

January 2011 in “ Korean Journal of Andrology ”

Keon‐Cheol Lee, Jong-Gu Kim, Sung Yong Cho, Joon Sung Jeon, In Rae Cho

doxazosin tamsulosin finasteride alpha-blocker lower urinary tract symptoms LUTS hypertensive males sexual function adverse events Cardura Flomax Propecia

TLDR The doxazosin plus tamsulosin combination improved symptoms effectively with fewer side effects.

The study compared the efficacy and safety of different alpha-blocker combinations in 374 hypertensive males with lower urinary tract symptoms (LUTS) unresponsive to 4 mg doxazosin. Patients were divided into three groups: increased doxazosin dose (D group), doxazosin plus tamsulosin (DT group), and doxazosin plus finasteride (DF group). After 1 year, the D and DT groups showed greater improvement in symptom scores and flow rates compared to the DF group. The D group experienced more vasodilatory adverse events, while the DF group had more sexual function adverse events. The DT combination offered similar efficacy to the D group but with fewer vasodilatory side effects, and it was more effective than the DF combination with similar vasodilatory side effects.

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