Clinicopathologic Features, Demographics, Disease Burden, and Therapeutics in Alopecic Sarcoidosis: A Case Series and Systematic Review

This study and systematic review of 77 cases of alopecic sarcoidosis, including a case series of 3 patients, highlights the significant impact of this condition, particularly among Black women, leading to scarring hair loss and psychosocial effects. The study emphasizes the need for early recognition and aggressive treatment to prevent scarring alopecia, with treatments like hydroxychloroquine and corticosteroids showing varying degrees of improvement. The review found limited high-quality evidence on treatment efficacy, particularly for tumor necrosis factor-alpha inhibitors, and noted that nonscarring alopecia patients generally had better outcomes. The study underscores the importance of biopsy for accurate diagnosis and suggests further research to understand the pathophysiology and improve treatment outcomes.