Alopecia Areata Profiling Shows lncRNAs Regulate the Suppressed Expression of Keratin

    September 2024 in “ PubMed ”
    Jing Qin Wu, Lan‐Xi Wu, Kun Yan, Junyou Li, Tao-Xiang Niu
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    TLDR Certain RNAs may help diagnose alopecia areata by affecting keratin genes.
    This study investigates the role of long non-coding RNAs (lncRNAs) in the pathogenesis of alopecia areata (AA), an autoimmune hair disease. Researchers collected skin tissues from both normal and bald areas of the scalp from 5 patients with AA and used RNA sequencing to analyze mRNA and lncRNA expression profiles. They identified 344 differentially expressed mRNAs and 116 lncRNAs, with functional enrichment analysis highlighting processes like keratinization and epithelial cell differentiation. The study found that 11 lncRNAs cis-regulate 15 target mRNAs, suggesting that keratin family genes are crucial in AA's pathogenesis. These findings offer new biomarkers for diagnosing alopecia areata.
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