TLDR Talquetamab may cause hair loss and skin issues.
Talquetamab, a novel bispecific antibody used for treating relapsed or refractory multiple myeloma, has been associated with skin-related adverse events but not previously with hair pathology. This report discusses a 74-year-old female patient on talquetamab therapy who developed alopecic patches, nail changes, glossitis, and keratoderma. A scalp biopsy confirmed alopecia areata, which responded to betamethasone dipropionate gel. The case suggests that talquetamab may cause adverse cutaneous effects due to cross-reactivity with GPRC5D-expressing keratinized structures, indicating a need for further research into the pathogenesis and treatment of these side effects.
45 citations,
January 2018 in “International Journal of Dermatology” Nail problems are common in people with alopecia areata, often leading to cosmetic and functional issues, but more research is needed for treatment guidelines.
51 citations,
December 2017 in “Skin Appendage Disorders” Stress may trigger hair loss by affecting immune protection in hair follicles.
26 citations,
October 2016 in “Case Reports in Dermatology” A man with severe hair loss saw hair and nail improvement after 10 months on tofacitinib without side effects.
64 citations,
March 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” GPRC5D is linked to the formation of hair, nails, and certain tongue areas.
6 citations,
November 2022 in “Journal of autoimmunity” JAK inhibitors like tofacitinib may effectively treat Alopecia Areata.
October 2022 in “Journal of Armed Forces Medical College, Bangladesh” Tofacitinib is effective and safe for treating alopecia areata.
39 citations,
April 2016 in “Case Reports in Dermatology” Tofacitinib temporarily regrew hair in a man with alopecia, but its effects didn't last.
5 citations,
June 2015 in “Veterinary dermatology” A dog with complete hair loss regrew most hair after treatment, with no relapse after stopping treatment.
39 citations,
April 2003 in “Australasian journal of dermatology” PUVA treatment led to significant hair regrowth in over half of the patients with alopecia areata totalis and universalis.
