Characterization and In Vivo Assay of Allantoin-Enriched Pectin Hydrogel for the Treatment of Skin Wounds

The study evaluates an allantoin-enriched pectin hydrogel for skin wound treatment using 16 female Wistar rats. The hydrogel demonstrated superior wound healing properties, achieving complete healing by Day 15, significantly faster than the control group's 24 days. It promotes angiogenesis, granulation, and re-epithelialization without disrupting the natural healing process. The hydrogel's biocompatibility, enhanced wettability, and porosity contribute to its effectiveness, suggesting it could be a promising option for wound dressings. Additionally, the hydrogel achieved full recovery of natural hair in the wound area within 15 days, highlighting its potential for minimally invasive treatment of chronic skin wounds.